SEROTONIN-REUPTAKE INHIBITORS (SRIS): FIRST-LINE MEDICATIONS FOR BDD- WHAT IS SEROTONIN?
Sunday, March 20th, 2011SEROTONIN-REUPTAKE INHIBITORS (SRIS): FIRST-LINE MEDICATIONS FOR BDD- WHAT IS SEROTONIN? Serotonin is one of the brain’s natural chemicals that transmits signals between nerve cells. These chemicals (neurotransmitters) are the chemical messengers that make the brain’s nerve cells fire and function. Healthy functioning of serotonin is important in many bodily functions, including mood, sleep, and appetite.The SRIs increase the amount of serotonin at the junction between nerve cells by preventing its reuptake, or reabsorption, into the releasing nerve cell (neuron). As a result, less serotonin is broken down, and more is then available to act on neurons that are “downstream.” This increased amount of serotonin between nerve cells in turn influences the activity of brain neurons. It appears that the SRIs increase overall serotonin transmission in the brain. They probably work by increasing serotonin availability at key brain areas. However, the serotonin system in the brain is extremely complex, and the SRIs’ overall effect on this system needs to be better understood. In addition, because different neurotransmitter systems are highly interconnected, the SRIs also influence other neurotransmitters, such as dopamine. Furthermore, it’s possible that the SRIs’ effect on serotonin isn’t what actually leads to decreased symptoms. This effect may simply be one step in a complicated chain of events.*243\204\8*